After you select your pitch, move your cursor towards the batter and press Y.
Use the cursor and put it exactly in the low middle.
Before the pitcher makes his selection, press R. When the pitch is thrown, your cursor will become small. If you hit the ball it will either be a home run, or a very hard hit.
At the team selection screen, press X to display an options screen that allows you to change such things as the difficulty, weather, stadium, and time of game.
After you select your pitch, move your cursor away from the batter and press Y.
Do the pickoff move. Then, as fast as possible (start selecting the "pitch" BEFORE the graphic even comes up), do the pickoff move again (try over if you must). If you do it fast enough, the runner will not lead off far enough, and will OVERRUN the bag coming back! Position your infielder over him, and he will be tagged out... every time. Great for "correcting" those fielding blunders we make sometimes. [Qualifiers: I have only tried this, so far, on the "Pro" level and against a CPU opponent.]
Reset The Count
While batting with a runner on any base, have the runner attempt a steal. Either go through with the steal or send him back. Quickly press Y before the view returns to your batter to reset the count to no balls and strikes.