| Title | Year | Genre |
|---|---|---|
| Empire Strikes Back, The | 1985 | Shooter |
| End, The | 1980 | Shooter |
| Endless Riches | 1999 | Slot machine |
| Enduro Racer | 1985 | Moto racing |
| Enforce | 1988 | Shooter |
| Enigma 2 | 1981 | Shooter |
| Enma Daio | 1993 | Other |
| Equites | 1984 | Shooter |
| Erotictac/Tactic | 1990 | Puzzle |
| Escape from Mars | 1980 | Arcade |
| Escape from the Planet of the Robot Monsters | 1989 | Action |
| Escape Kids | 1991 | Racing |
| ESP Ra.De. | 1998 | Shooter |
| Espgaluda | 2003 | Shooter |
| Espial | 1983 | Shooter |
| Every Second Counts | 1990 | Quiz |
| Evil Night | 1998 | Gun shooter |
| Evil Stone | 1990 | Arcade |
| Evolution Soccer | 2001 | Soccer |
| Excelsior | 1996 | Action |
| Excite League | 1988 | Baseball |
| Exciting Animal Land Jr. | 1993 | Arcade |
| Exciting Soccer | 1983 | Soccer |
| Exciting Soccer II | 1984 | Soccer |
| Exed Exes | 1985 | Shooter |
| Exerion | 1983 | Shooter |
| Exodus | ???? | Shooter |
| Explosive Breaker | 1992 | Shooter |
| Express Card / Top Card | 1998 | Cards |
| Express Raider | 1986 | Action |
| Extermination | 1987 | Shooter |
| Exterminator | 1989 | Shooter |
| Extra Bases | 1980 | Baseball |
| Extra Inning | 1978 | Baseball |
| Extreme Downhill | 1995 | Skiing |
| Exvania | 1992 | Arcade |
| Exzisus | 1987 | Shooter |
| Eyes | 1982 | Arcade |
| F-1 Dream | 1988 | F1 racing |
| F-1 Grand Prix | 1991 | F1 racing |
| F-1 Grand Prix Part II | 1992 | F1 racing |
| F-1 Grand Prix Star II | 1993 | F1 racing |
| F-15 Strike Eagle | 1991 | Aerial fighting |
| F1 Exhaust Note | 1993 | F1 racing |
| F1 Super Lap | 1993 | F1 racing |
| Face Off | 1988 | Hockey |
| FairyLand Story, The | 1985 | Arcade |
| Falcon | ???? | Shooter |
| FamicomBox | 1986 | Compilation |
| Fancy World - Earth of Crisis | 1996 | Action |
