| Title | Year | Genre |
|---|---|---|
| SDI - Strategic Defense Initiative | 1987 | Shooter |
| Sea Battle | 1980 | Arcade |
| Sea Fighter Poseidon | 1984 | Shooter |
| Sea Hunter Penguin | 1995 | Arcade |
| Sea Wolf | 1976 | Shooter |
| Sea Wolf II | 1978 | Shooter |
| Search Eye | 1999 | Puzzle |
| Search Eye | 1999 | Puzzle |
| Search Eye Plus V2.0 | 1999 | Puzzle |
| Second Love | 1986 | Mahjong |
| Section Z | 1985 | Shooter |
| See See Find Out | 1999 | Arcade |
| Sega Ninja | 1985 | Action |
| Sega Rally 2 | 1998 | Racing |
| SegaSonic Cosmo Fighter | 1993 | Arcade |
| SegaSonic the Hedgehog | 1994 | Platform |
| Seibu Cup Soccer | 1992 | Soccer |
| Seicross | 1984 | Shooter |
| Seiha | 1987 | Mahjong |
| Sel Feena | 1991 | Arcade |
| Sel-Jan | 1983 | Mahjong |
| Sen Jin - Guardian Storm | 1998 | Shooter |
| Sen-Know | 1999 | Puzzle |
| Sengeki Striker | 1997 | Shooter |
| Sengoku Blade - Sengoku Ace Episode II | 1996 | Shooter |
| Sengoku Mahjong | 1991 | Mahjong |
| Sengoku no Jieitai | 1980 | Action |
| Senjyo | 1983 | Shooter |
| Senkyu | 1995 | Puzzle |
| Sex Appeal | 1992 | Quiz |
| Sex Triv | 1985 | Quiz |
| Sexual Trivia | 1985 | Quiz |
| Sexy Boom | 1992 | Puzzle |
| Sexy Gal | 1985 | Mahjong |
| Sexy Parodius | 1996 | Shooter |
| SF-HiSplitter | 1979 | Shooter |
| SF-X | 1983 | Shooter |
| Shackled | 1986 | Action |
| Shadow Dancer | 1989 | Action |
| Shadow Force | 1993 | Beat em up |
| Shadow Land | 1987 | Action |
| Shadow Warriors | 1988 | Beat em up |
| Shanghai | 1988 | Puzzle |
| Shanghai II | 1989 | Puzzle |
| Shanghai III | 1993 | Puzzle |
| Shanghai Kid | 1985 | Fighting |
| Shanghai Matekibuyuu | 1998 | Puzzle |
| Shanghai Sangokuhai Tougi | 2002 | Puzzle |
| Shanghai Shoryu Sairin | 2000 | Puzzle |
| Shark Attack | 1980 | Arcade |
