| Title | Year | Genre |
|---|---|---|
| Shuttle - The Space Flight Simulator | ???? | Adventure |
| Side Arms | ???? | Shooter |
| Side Winder | 1988 | Shooter |
| Side Winder II | 1989 | Shooter |
| Sidewalk | 1987 | Adventure |
| Siegemaster | ???? | Strategy |
| Silent Service | 1986 | Strategy |
| Silent Service II | 1991 | Action |
| Silicon Knights | 1988 | Shooter |
| Silkworm | 1988 | Shooter |
| Sim City | 1989 | Management |
| Sim City Terrain Editor | 1991 | Software |
| Simpsons - Bart vs the World, The | 1993 | Arcade |
| Simpsons, The - Bart vs. the Space Mutants | 1991 | Platform |
| Simulcra | 1990 | Arcade |
| Skate Ball | 1989 | Sports |
| Skate Tribe | ???? | Skateboarding |
| Skidoo | ???? | Sports |
| Skidz | 1990 | Skateboarding |
| Skiing Contest | ???? | Arcade |
| Skrull | ???? | Action |
| Skull & Crossbones | ???? | Action |
| Skulldiggery | ???? | Arcade |
| Skweek | 1989 | Arcade |
| Sky Chase | 1988 | Aerial fighting |
| Sky Fox 2 | 1989 | Action |
| Skyfox | 1986 | Action |
| Skystrike | ???? | Shooter |
| Slackskin and Flint | 1992 | Action |
| Slap Fight | ???? | Shooter |
| Slayer | ???? | Shooter |
| Slaygon | ???? | Adventure |
| Sleepwalker | 1993 | Platform |
| Sleuth | ???? | Adventure |
| Sliders | ???? | Arcade |
| Sliding Block Puzzle | 1988 | Puzzle |
| Slightly Magic | ???? | Adventure |
| Slippery Sid | ???? | Arcade |
| Slug | ???? | Puzzle |
| Smash TV | 1992 | Shooter |
| Snoball in Hell | 1991 | Breakout |
| Snoopy and Peanuts | ???? | Adventure |
| Snow Strike | ???? | Aerial fighting |
| Snowball | 1986 | Adventure |
| Soccer King | ???? | Soccer |
| Soccer Supremo | 1988 | Soccer |
| Soko ST | ???? | Puzzle |
| Sol Negro - Female | ???? | Action |
| Sol Negro - Male | ???? | Action |
| Soldier 2000 | ???? | Action |
