| Title | Year | Genre |
|---|---|---|
| Super Robot Taisen W | 2007 | Strategy |
| Super Scribblenauts - Les Énigmes de Maxwell | 2010 | Puzzle |
| Super Scribblenauts | 2010 | Puzzle |
| Super Speed Machines | 2010 | Racing |
| Super Star Kartz | 2011 | Racing |
| Superman Returns | 2006 | Action |
| Supermodel Makeover by Lauren Luke | 2009 | Adventure |
| Supervivientes | 2009 | Adventure |
| Surf's Up | 2007 | Racing |
| Survival Kids - Chiisana Shima no Ookina Himitsu!? | 2007 | Adventure |
| Survival Kids - Lost in Blue | 2005 | Adventure |
| Survival Kids - Lost in Blue 2 | 2007 | Adventure |
| Survivor | 2010 | Adventure |
| Sushi Academy | 2008 | Arcade |
| Sushi Go-Round | 2010 | Arcade |
| Susja ro Chatneun Geurim Puzzle - Picross DS | 2007 | Puzzle |
| Suske en Wiske - De Texas Rakkers | 2009 | Action |
| Suugaku Master DS | 2009 | Software |
| Suujin Taisen | 2007 | Puzzle |
| Suzuki Super-bikes II - Riding Challenge | 2008 | Moto racing |
| Suzumiya Haruhi no Chokuretsu | 2009 | Adventure |
| Sweet 16 | 2009 | Adventure |
| Sword World 2.0 - Game Book DS | 2009 | Adventure |
| Syberia | 2008 | Adventure |
