| Title | Year | Genre |
|---|---|---|
| Samurai Shodown | ???? | Fighting |
| Sangokushi III | ???? | Strategy |
| Schwarzschild | ???? | Strategy |
| Secret of Monkey Island | ???? | Adventure |
| Sega Classics Arcade Collection | 1992 | Compilation |
| Sega Classics Arcade Collection | ???? | Compilation |
| Sengoku Densho | 1991 | Beat em up |
| Sensible Soccer | 1993 | Soccer |
| Sewer Shark | 1993 | Shooter |
| Shadow of the Beast 2 | ???? | Action |
| Shadowrun | 1996 | Adventure |
| Shining Force CD | ???? | RPG |
| Silky Lip | 1992 | RPG |
| Silpheed | ???? | Shooter |
| SimEarth | 1993 | Management |
| Sin Megami Tensei | ???? | RPG |
| Smurfs, The | ???? | Platform |
| Snatcher | ???? | Adventure |
| Sol-Feace | ???? | Shooter |
| Sonic CD | ???? | Platform |
| Soul Star | ???? | Shooter |
| Space Ace | ???? | Adventure |
| Spiderman vs. Kingpin | 1993 | Platform |
| Star Wars - Rebel Assault | ???? | Shooter |
| Star Wars Chess | ???? | Chess |
| Starblade | 1994 | Gun shooter |
| Stellar Fire | ???? | Shooter |
| Super League CD | 1993 | Baseball |
| Super Strike Trilogy | ???? | Compilation |
| Supreme Warrior | 1994 | Fighting |
| Surgical Strike | 1995 | Gun shooter |
| Switch | 1993 | Adventure |
| Syndicate | 1994 | Action |
